Ribosome RNA Sequencing Service
Creative Biolabs is a leading service provider that focuses on ribosomal transcriptome research. Based on our advanced platforms and extensive experience, now we can provide novel ribosome RNA sequencing services for our clients all over the world.
Background
Ribosome RNA sequencing is the technology to determine the actively translated mRNA in samples. In combination with high-throughput next-generation sequencing (NGS), it allows systematic monitoring of cellular translation processes and prediction of protein abundance. Compared to RNA-Seq technologies that can quantify mRNA abundance across the transcriptome, our ribosome RNA sequencing technology can also provide transcriptome-wide information on protein synthesis. What's more, the high resolution of this technique allows detailed analysis of ribosome density on individual RNAs. Our ribosome RNA sequencing technology has successfully performed a range of studies in both prokaryotes and eukaryotes.
Fig. 1 Ribo-seq analysis of translation in the Ribo-T cells.¹
Our Service
Creative Biolabs offers comprehensive ribosome RNA sequencing services, including:
- Ribosome RNA Isolation: We employ optimized protocols for extracting high-quality ribosome RNA from diverse sample types, ensuring minimal degradation and contamination.
- High-Throughput Sequencing: Utilizing cutting-edge next-generation sequencing (NGS) platforms, we provide high-resolution sequencing data with exceptional coverage and accuracy.
- Data Analysis and Interpretation: Our bioinformatics team delivers detailed data interpretation, including identification of ribosomal RNA variants, post-transcriptional modifications, and gene expression profiling linked to ribosomal functions.
Highlights
- Comprehensive Solutions
We provide end-to-end support, from RNA extraction to advanced data analysis, ensuring a streamlined workflow and reliable results.
- Customizable Options
We offer tailored services that cater to specific research needs, including custom sequencing approaches for rare or complex ribosomal RNA variants.
- High-Quality Data
Our rigorous quality control measures ensure accurate, reproducible, and publication-ready data, allowing for confident conclusions.
- Expert Bioinformatics Support
We offer advanced bioinformatics analysis, ensuring thorough data interpretation, including insights into RNA modifications, differential expression, and ribosomal variant identification, enabling a deeper understanding of ribosomal biology.
- Innovative Approaches
Our ribosome RNA sequencing services incorporate cutting-edge techniques, such as single-cell RNA sequencing and RNA modification mapping, to provide a comprehensive view of ribosome function and composition.
FAQs
Q1: What types of samples can be used for ribosome RNA sequencing?
A: We accept a broad range of samples, including cell cultures, tissues, and specialized biological models. Our team can advise you on optimal sample preparation techniques.
Q2: Can I request specific regions of the ribosome RNA to be sequenced?
A: Yes, we offer customizable sequencing options, allowing you to target specific regions of the ribosome RNA, ensuring your project objectives are met.
Q3: What output will I receive?
A: We provide comprehensive sequencing reports, including raw data files, detailed gene expression profiles, and insights into RNA modifications. Our team will also assist with data interpretation.
Q4: How does ribosome RNA sequencing differ from regular RNA sequencing?
A: Ribosome RNA sequencing specifically focuses on ribosomal RNA and related transcripts, providing detailed insights into ribosome composition, variants, and post-transcriptional modifications, which are crucial for understanding translation processes in cells.
Q5: Can this service help identify ribosomal RNA mutations?
A: Yes, our ribosome RNA sequencing service can detect mutations, variants, and modifications in ribosomal RNA, offering insights into functional changes that may impact protein synthesis.
Resource
Ribosome Analysis - Creative Biolabs
Ribosome Analysis - Creative BiolabsCreative Biolabs has been a long-term expert in the field of ribosome research. Based on our extensive experience and advanced platforms, we are confident in offering a series of ribosome-related services, including ribosome separation and extraction services, ribosome analysis services, as well as ribosomal marker antibody development services. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.
Reference
- Aleksashin, Nikolay A., et al. "Assembly and functionality of the ribosome with tethered subunits." Nature communications 10.1 (2019): 930.
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