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Ribosome RNA Sequencing Services

Creative Biolabs is a leading service provider that focuses on ribosomal transcriptome research. Based on our advanced platforms and extensive experience, now we can provide novel ribosome RNA sequencing services for our clients all over the world.

Introduction of Ribosome RNA Sequencing

Ribosome RNA sequencing is the technology to determine the actively translated mRNA in samples. In combination with high-throughput next-generation sequencing (NGS), it allows systematic monitoring of cellular translation processes and prediction of protein abundance. Compared to RNA-Seq technologies that can quantify mRNA abundance across the transcriptome, our ribosome RNA sequencing technology can also provide transcriptome-wide information on protein synthesis. What's more, the high resolution of this technique allows detailed analysis of ribosome density on individual RNAs. Our ribosome RNA sequencing technology has successfully performed a range of studies in both prokaryotes and eukaryotes.

Fig. 1 Translation in the Ribo-T cells. (Aleksashin, Nikolay A., et al., 2019)Fig. 1 Ribo-seq analysis of translation in the Ribo-T cells.¹

Ribosome RNA Sequencing Service in CBL

After obtaining the cell or tissue samples, we first digest free mRNA with nucleases and then enrich them for ribosome-mRNA complexes. Finally, the target RNA fragment can be obtained. According to the subsequent library construction and data analysis, the protein translation levels can be determined. Our strong bioinformatics team can meet various in-depth data analysis needs of our customers.

Applications of Ribosome RNA Sequencing

Ribosome RNA sequencing technology plays an important role in several fields by measuring the level of gene expression during translation. In addition, the combination of this technology with other techniques such as RNA-seq, IP, or ChIP further expands its range of applications. Its main applications include but are not limited to:

  • Determining the translation start point
  • Determining the protein synthesis rate
  • Prediction of protein abundance
  • Research on the control of the translation process
  • Research on gene deregulation and translational regulation
  • Identifying translated mRNA regions
  • Observe how nascent peptides are folded
  • Measuring the amount of synthesized proteins

Advantages of Our Ribosome RNA Sequencing Services

  • Suitable for various sample types
  • Well-trained scientists and extensive experience
  • Low price and high-quality service
  • Customized services based on standard processes to meet the different needs of customers

Creative Biolabs has been a long-term expert in the field of ribosome research. Based on our extensive experience and advanced platforms, we are confident in offering a series of ribosome-related services, including ribosome separation and extraction services, ribosome analysis services, as well as ribosomal marker antibody development services. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.

Reference

  1. Aleksashin, Nikolay A., et al. "Assembly and functionality of the ribosome with tethered subunits." Nature communications 10.1 (2019): 930.
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