Frontier Overview of Ribosome Research

Differences in Human and Bacterial Ribosome Decoding

Ribosomes are important molecular machines in the cell that synthesizes proteins by precisely decoding the nucleotide sequence of messenger RNA (mRNA) using amino aminoacyl-tRNA substrates. By performing mechanistic studies of bacterial and human ribosomes, researchers can...

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New Class of Ribosomal Peptide with Two Amino Termini

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large class of natural products synthesized by ribosomes and post-translationally modified. These peptides play important roles in many biological processes, including cell signaling, immune response and antimicrobial defense...

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The Mysterious Link Between Ribosomes and Major Depressive Disorder

Relatively little is known about the potential biological mechanisms underlying the heterogeneous manifestation of Major Depressive Disorder (MDD). This emphasizes the need for a conceptual framework to explain the variability, and to bridge the gap between animal models and clinical endpoints...

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