Services
In recent years, as one of the important components of biological life processes, ribosomes have become a hot spot in the field of biology. With experienced scientists and perfect experimental techniques, Creative Biolabs has successfully developed a series of ribosome isolation and analysis solutions to provide our global customers with fast, high-quality, and convenient ribosome services.
Background
Introduction to Ribosomes
Ribosomes are complex molecular machines that exist in all living cells. Ribosomes are at the core of translation in all living organisms. The translation is an important process in life activities and a key step in gene expression, which converts the genetic information carried by messenger RNA (mRNA) into polypeptides or proteins with specific structures and functions. In general, the main functions of ribosomes include decoding information and forming peptide bonds. The two functions reside in two ribonucleoprotein particles (RNPs) of different sizes, which are also known as ribosomal subunits. Each subunit consists of ribosomal protein (r-protein) and ribosomal RNA (rRNA). The small subunit has a decoding function while the large subunit is responsible for catalyzing the formation of peptide bonds.
Fig.1 Structure of the ribosome with bound tRNAs. (Rodnina, 2007)
Importance of Ribosomes
Ribosomes provide the basis for protein production, which drives cell growth. Transcription of ribosomal RNA is closely related to cellular energy state and the production of ribosomal proteins. Ribosomal biogenesis has been implicated in a variety of diseases, especially cancer and hematologic diseases. In addition, studies have shown that ribosomes are also linked to aging. Exploring the structure of ribosomes and related factors will be beneficial to further clarify the molecular mechanism behind these connections.
Our Service
After years of practice and accumulation, Creative Biolabs has successfully completed many ribosome-related projects. With advanced technology, we provide diverse ribosome-related services. Our services include but are not limited to:
- Ribosome Separation and Extraction Services
- Ribosome Analysis Services
- Ribosomal Marker Antibody Development Services
Highlights
- Professional team
Our scientists have excellent theoretical knowledge and extensive experimental experience dedicated to ribosome isolation and analysis.
- Extensive biological sample types
We accept a wide range of biological samples, including tissues and cells. Sample sources include humans, animals, plants, and microorganisms.
- Professional bioinformatics analysis
We have a professional bioinformatics analysis technical team as well as complete hardware equipment, analysis tools, and data analysis charters.
- One-stop service
We provide convenient and fast one-stop ribosome isolation and analysis services to advance your project.
FAQs
Q1: What can Creative Biolabs do about ribosomes?
A: Creative Biolabs has successfully developed a series of ribosome isolation and analysis solutions. We provide diverse services including ribosome separation and extraction, ribosome analysis, and ribosomal marker antibody development services. Leveraging our scientific expertise and advanced technology, handle a wide range of biological samples, conduct professional bioinformatics analysis, and offer convenient one-stop services to advance your project.
Q1: What are the features of Creative Biolabs' services?
A: Creative Biolabs boasts a team of scientists with excellent theoretical knowledge and extensive experimental experience dedicated to ribosome isolation and analysis. We accept a wide range of biological samples and provide professional bioinformatics analysis. And also offer fast and convenient one-stop services for all aspects of ribosome research.
Published Data
Ribosome profiling: A Hi-Def monitor for protein synthesis at the genome-wide scale
WILEY INTERDISCIPLINARY REVIEWS: RNA
Authors: Audrey Michel, Pavel V Baranov
Abstract: Ribosome profiling or ribo-seq is a new technique that provides genome-wide information on protein synthesis (GWIPS) in vivo. It is based on the deep sequencing of ribosome protected mRNA fragments allowing the measurement of ribosome density along all RNA molecules present in the cell. At the same time, the high resolution of this technique allows detailed analysis of ribosome density on individual RNAs. Since its invention, the ribosome profiling technique has been utilized in a range of studies in both prokaryotic and eukaryotic organisms. Several studies have adapted and refined the original ribosome profiling protocol for studying specific aspects of translation. Ribosome profiling of initiating ribosomes has been used to map sites of translation initiation. These studies revealed the surprisingly complex organization of translation initiation sites in eukaryotes. Multiple initiation sites are responsible for the generation of N-terminally extended and truncated isoforms of known proteins as well as for the translation of numerous open reading frames (ORFs), upstream of protein coding ORFs. Ribosome profiling of elongating ribosomes has been used for measuring differential gene expression at the level of translation, the identification of novel protein coding genes and ribosome pausing. It has also provided data for developing quantitative models of translation. Although only a dozen or so ribosome profiling datasets have been published so far, they have already dramatically changed our understanding of translational control and have led to new hypotheses regarding the origin of protein coding genes.
Outline of the major steps of the ribosome profiling protocol. Michel, Audrey M., Pavel V. Baranov.;2013
PResource
Ribosome Analysis - Creative Biolabs
Ribosome Analysis - Creative BiolabsCreative Biolabs provides comprehensive ribosome services, from initial ribosome isolation and library preparation to final data analysis and interpretation. Leveraging the unparalleled experience and expertise of our world-class team of molecular biologists and bioinformaticians, we can help you achieve satisfactory results quickly. We also provide custom services to meet your project needs. If you are interested, please contact us for more information and a detailed quotation.
Reference
- Rodnina, M. V.; et al. How ribosomes make peptide bonds. Trends in biochemical sciences. 2007, 32(1): 20-26.
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