Ribosome Analysis Services

As an important macromolecular translation machine in organisms, ribosomes are inseparable from life activities such as protein synthesis and cell proliferation. In recent years, scientists have become more and more interested in the study of ribosome-related factors. As a global reputable ribosome service provider, Creative Biolabs is pleased to provide ribosome analysis services to our customers worldwide.

Background

Ribosomes are complexes of RNA and protein. Ribosomes are large molecular machines that translate sequences of messenger RNA into proteins in all living cells. Furthermore, there is a close correlation between ribosome biogenesis and cell proliferation. There is increasing evidence that dysregulated ribosome biosynthesis is closely associated with an increased risk of cancer and metabolic disorders. Analysis of ribosomes has identified some of the factors involved in these complex processes, providing new perspectives for further in-depth study of ribosome properties and functions.

Our Service

Ribosomal Transcriptome

Both biological sciences and medicine rely on rapid genomic and transcriptomic analysis techniques to probe cellular state, physiology, and activity. Among the technologies, microarray technology and next-generation transcript sequencing (RNA-Seq) are the most advanced. Among them, RNA-Seq offers limitless possibilities in modern biological analysis. For the ribosomal transcriptome, the analysis mainly involves cDNA libraries from short mRNA fragments covered by ribosomes.

Fig. 1 Stress-responsive mRNA translation is constitutively activated on loss of Rcm1.¹ profiling protocol. (McGlincy, 2017)

Ribosomal Proteomics

In recent years, proteomics research has made great progress with the development of technology. But ribosomal proteomics still lags. Recently, with the rise of the ribosomal filtering hypothesis and ribosome-specific regulatory capabilities, ribosomal proteomics has emerged as an important strategy for understanding the mechanism of ribosome translation. Undoubtedly, the development of ribosomal proteomics provides a promising strategy for explaining the properties and roles of ribosomal proteins.

Fig. 1 Three-tiered mass spectrometry based approach for the dissection and characterization of ribosomal particles.¹

Highlights

• Industry leadership

Our industry-leading expertise in ribosome extraction and analysis can help advance your project.

• Perfect experimental platform

We have established a complete experimental platform for ribosome purification and analysis.

• Professional research team

Our excellent research team specializes in theoretical knowledge and practical skills in ribosome isolation and analysis.

• Abundant experience

We have successfully completed many ribosome projects and accumulated rich experience. We can provide a professionally customized process according to your project needs.

• One-stop service of high quality

Our team can provide diverse and low-cost, high-efficiency one-stop ribosome analysis services.

FAQs

Resource

Ribosome Analysis - Creative Biolabs Ribosome Analysis - Creative Biolabs

As a leader in the field of ribosome research, Creative Biolabs aims to provide high-quality ribosome extraction and analysis services to customers around the world. Our customized services will greatly contribute to the success of your project. Please contact us for more information and a detailed quotation.

References

1. Schosserer, Markus, et al. "Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan." Nature communications 6.1 (2015): 6158.
2. Van de Waterbeemd, Michiel, et al. "Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods." Nature communications 9.1 (2018): 2493.