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Ribosome-Interacting Proteins Analysis

Ribosomes are essential components of the protein synthesis machinery, while ribosome-interacting proteins have critical roles in diverse cellular functions that are distinct from their primary role in ribosome biogenesis and act as biomarkers and molecular targets in the diagnosis and treatment of human diseases. Therefore, the overall analysis of ribosome-interacting proteins can promote the understanding of various related diseases. As an advanced biotech company, Creative Biolabs has launched comprehensive one-stop Ribosome-interacting Proteins Analysis services to solve your problems in related research. Based on our established protein analysis platforms, our customized proteomics services have achieved remarkable goals in disease diagnosis, pathological research, and drug discovery. Thus, we are confident to provide you with the best services.

Introduction to Ribosome-interacting Proteins

The eukaryotic ribosome consists of four ribosomal RNA species and 79 ribosomal proteins, which act as a central effector of protein synthesis in all organism kingdoms. More and more evidence indicates that the ribosome and associated proteins play a critical role in normal cellular physiology, cellular responses to internal and external environmental stimuli, and the pathogenesis of human diseases. Several human diseases have been demonstrated to be associated with defects in ribosome biogenesis, including increased cancer susceptibility. Moreover, Diamond-Blackfan anemia and 5q-syndrome are two clinical syndromes associated with impairments in erythropoiesis that are attributed to ribosomal-interacting protein mutations. In recent years, there has been an increasing interest in further elucidating the roles of ribosomal-interacting proteins in both normal physiological processes and the pathogenesis of human diseases.

Fig. 1 Multiple experiments to explore the ribosome-bound intermediate states are partially folded. (Chan, Sammy HS, et al., 2022)Fig. 1 The ribosome-bound intermediate states are partially folded.¹

Our Ribosome-interacting Proteins Analysis Services

Over the past few decades, proteomic research has seen unprecedented development due to technological advancement and several subcellular proteomic studies have been initiated including mitochondrial proteomics, membrane proteomics, and ribosomal proteomics, while ribosomal proteomics has become a promising chapter for both proteomic and ribosomal research. Therefore, Creative Biolabs launched a Ribosome-interacting Proteins Analysis Service Package containing a variety of Quantification, Relative Abundance Analysis, Network-based Cluster Analysis, Protein Interaction Analysis, and Protein Modification Detection. In this way, a comprehensive and accurate ribosomal proteomics analysis result will be developed.

The biosynthesis of ribosomes, the molecular machines that translate messenger RNA (mRNA) into proteins, is a fundamental biological process that is intimately linked to cell growth. The quantification of ribosomal proteins can reflect the ribosomal function directly. Creative Biolabs offers rapid and precise quantification of ribosomal protein services based on our mature proteomics platforms.

Ribosome biogenesis is a highly dynamic and coordinated process that is exquisitely regulated by multiple signaling pathways and ribosome-interacting proteins, while the relative abundance shows the different phenotypes of ribosomes and their relationship with diseases. Creative Biolabs offers relative abundance analysis for ribosomal proteins as well as other customized proteomics analyses for our clients based on our comprehensive platforms.

Network-based cluster analysis is a novel pathway in proteomic analysis in such a way to classify proteins in the same group are more similar to each other than to those in other groups. Based on our novel platforms and skilled groups, network-based cluster analysis has been applied in the proteomics analysis of ribosomal proteins in Creative Biolabs and customized proteomics analyses are also available for our clients.

The ribosome is a complex subcellular unit composed of a variety of proteins. Thus, the interaction of different proteins is the basis of the cellular translational machinery, while clear protein interaction is important to the research of ribosome-related diseases. Creative Biolabs offers the detection of various protein interactions including ribosomal proteins.

Many protein functions depend on the modification after translation, while the mutation, missing, false modification, and folding error lead to the loss of function of ribosomes. Creative Biolabs provides the detection of protein modification by various means and offers a comprehensive series of customized proteomics analyses to our clients.

Creative Biolabs offers our clients various modules that cover every aspect of the Ribosome-interacting Proteins Analysis service. We are confident in presenting a comprehensive set of services to explain the secrets of the ribosome-interacting proteins to worldwide clients. For more details of our service, please feel free to contact us to assist you.

Reference

  1. Chan, Sammy HS, et al. "The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein." Nature chemistry 14.10 (2022): 1165-1173.
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